Increased apparent blood flow and volume of the choroid plexus in the Alzheimer’s Disease patients

Background Recent works suggested the association between dysfunctional glymphatic system and Alzheimer's Disease, which shows as alternated cerebrospinal fluid production. It is believed that choroid plexus major site of CSF production conventionally blood flow related to rate directly. Therefore, we investigated perfusion in AD patients using arterial spin labeling (ASL) MRI retrospectively. Method 21 (15 males, 76.1±5.7 years), 36 MCI (20 72.6±7.9 88 healthy controls (40 74.8±8.0 years) from ADNI3 were included this study. The lateral regions segmented automatically based on a 3D U-net deep learning method, has been demonstrated with higher accuracy compared Freesurfer. In addition, gray matter mask was T1 weighted images SPM12, it used transfer ASL M0 image space. Relative cerebral quantified by first dividing its smoothed (a Gaussian filter sigma 4 pixels), then normalizing mean signal region region. chosen probability than 0.5. Result nonparametric Mann-Whitney U test, volume (1.58±0.40ml) significantly larger (p = 0.036) (1.41±0.39). (0.85±0.30) showed 0.017) relative (0.70±0.20). Conclusion enlarged increased may suggest over-compensation patients. However, further investigation required separate at